Limit Of Quantitation: The smallest detectable concentration an analytical instrument can determine at a given confidence level. IUPAC defines the quantitative detection limit as Cld = ks/m, where k is 10, s is the standard deviation of instrument readings taken on a 'blank' (a solution with zero concentration of analyte), and m is the slope of a plot of instrument response vs. Concentration, as calculated by linear regression.

 

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